插入序列 ISAba11 参与鲍曼不动杆菌的多粘菌素耐药和脂多糖丢失。
Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.
机构信息
Department of Microbiology, Monash University, Victoria, Australia.
出版信息
Antimicrob Agents Chemother. 2011 Jun;55(6):3022-4. doi: 10.1128/AAC.01732-10. Epub 2011 Mar 14.
Abstract
Infections caused by Acinetobacter baumannii are of increasing concern, largely due to the multidrug resistance of many strains. Here we show that insertion sequence ISAba11 movement can result in inactivation of the A. baumannii lipid A biosynthesis genes lpxA and lpxC, resulting in the complete loss of lipopolysaccharide production and high-level colistin resistance.
摘要
鲍曼不动杆菌引起的感染越来越受到关注，主要是由于许多菌株具有多药耐药性。在这里，我们表明插入序列 ISAba11 的移动可导致鲍曼不动杆菌脂质 A 生物合成基因 lpxA 和 lpxC 的失活，导致脂多糖产生完全丧失和高水平的多粘菌素耐药性。
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