sir-2.1转基因对秀丽隐杆线虫寿命的调控。 - Suppr

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Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes.

作者信息

Viswanathan Mohan, Guarente Leonard

机构信息

Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139, USA.

出版信息

Nature. 2011 Sep 21;477(7365):E1-2. doi: 10.1038/nature10440.

DOI:10.1038/nature10440

PMID:21938026

Abstract

摘要

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The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction.

Mech Ageing Dev. 2009 Nov-Dec;130(11-12):762-70. doi: 10.1016/j.mad.2009.10.001.

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

Cell. 2006 Jun 16;125(6):1165-77. doi: 10.1016/j.cell.2006.04.036.

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.

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Nature. 2001 Mar 8;410(6825):227-30. doi: 10.1038/35065638.

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相似文献

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Nature. 2011 Sep 21;477(7365):E1-2. doi: 10.1038/nature10440.

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

Nature. 2001 Mar 8;410(6825):227-30. doi: 10.1038/35065638.

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Science. 2001 Apr 6;292(5514):41-3. doi: 10.1126/science.292.5514.41.

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Nature. 2004 May 13;429(6988):149-52. doi: 10.1038/429149a.

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Indian J Med Sci. 2000 Sep;54(9):403-4.

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Curr Biol. 2000 Oct 5;10(19):R708-11. doi: 10.1016/s0960-9822(00)00714-4.

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Trends Biochem Sci. 2000 Dec;25(12):644. doi: 10.1016/s0968-0004(00)01706-0.

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本文引用的文献

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

PLoS Genet. 2011 Sep;7(9):e1002235. doi: 10.1371/journal.pgen.1002235. Epub 2011 Sep 1.

The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction.

Mech Ageing Dev. 2009 Nov-Dec;130(11-12):762-70. doi: 10.1016/j.mad.2009.10.001.

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

Cell. 2006 Jun 16;125(6):1165-77. doi: 10.1016/j.cell.2006.04.036.

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.

Dev Cell. 2005 Nov;9(5):605-15. doi: 10.1016/j.devcel.2005.09.017.

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

Nature. 2001 Mar 8;410(6825):227-30. doi: 10.1038/35065638.

Regulation of lifespan by sensory perception in Caenorhabditis elegans.

Nature. 1999 Dec 16;402(6763):804-9. doi: 10.1038/45544.