辐射治疗后的前列腺癌长期恢复会增加癌症干细胞。
Long-term recovery of irradiated prostate cancer increases cancer stem cells.
机构信息
Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
出版信息
Prostate. 2012 Dec 1;72(16):1746-56. doi: 10.1002/pros.22527. Epub 2012 Apr 18.
BACKGROUND
Despite improvements in treatment, prostate cancer (PC) remains the second-leading cause of cancer death in men. Radiotherapy is among the first-line treatments for PC, but a significant number of patients relapse. Recent evidence supports the idea that PC is initiated by a subset of cells, termed cancer stem cells (CSCs). CSCs have also been implicated in radioresistance in various malignancies, but their role in PC has not yet been investigated.
METHODS
We compared the relative radiosensitivity of isolated CSCs to the total population of their corresponding cell lines, and examined the relative numbers of CSCs in irradiated cell lines following long-term recovery and in recurrent human PC.
RESULTS
Here, we show that while irradiation does not immediately favor increased survival of CSCs, irradiated PC cell lines showed an increase in CSC properties with long-term recovery. These data suggest that, although CSCs are initially damaged by radiation, they possess a greater capacity for recovery and regrowth.
CONCLUSIONS
The combination of radiotherapy with a CSC-targeted therapeutic strategy may prevent tumor recurrence.
背景
尽管治疗有所改善，但前列腺癌（PC）仍然是男性癌症死亡的第二大主要原因。放射疗法是 PC 的一线治疗方法之一，但仍有相当数量的患者复发。最近的证据支持这样一种观点，即 PC 是由一小部分被称为癌症干细胞（CSC）的细胞引发的。CSC 也与各种恶性肿瘤的放射抗性有关，但它们在 PC 中的作用尚未得到研究。
方法
我们比较了分离的 CSC 与相应细胞系的总群体的相对放射敏感性，并在长期恢复后和复发性人类 PC 中检查了照射细胞系中的 CSC 相对数量。
结果
在这里，我们表明，虽然照射不会立即有利于 CSC 存活的增加，但照射后的 PC 细胞系在长期恢复后表现出 CSC 特性的增加。这些数据表明，尽管 CSC 最初受到辐射的损害，但它们具有更大的恢复和再生能力。
结论
放射疗法与 CSC 靶向治疗策略的结合可能预防肿瘤复发。
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