宿主细胞因子 1 抑制 SKN-1 调节秀丽隐杆线虫的氧化应激反应。
Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
出版信息
Aging Cell. 2012 Aug;11(4):717-21. doi: 10.1111/j.1474-9726.2012.00831.x. Epub 2012 Jun 4.
Abstract
Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1.
摘要
宿主细胞因子-1 (HCF-1) 是 DAF-16/FOXO 寿命和应激反应功能的保守调节剂。SKN-1 转录因子是一种进化上保守的外来应激调节剂和促长寿因子。在这里，我们证明 SKN-1 有助于增强 hcf-1 突变引起的秀丽隐杆线虫的氧化应激抗性。HCF-1 阻止 SKN-1 的核积累，并特异性地抑制参与细胞解毒途径的靶基因的 SKN-1 的转录激活。我们的发现揭示了两种高度保守的寿命和应激反应因子 HCF-1 和 SKN-1 之间的一种新的、特定于上下文的调节关系。
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本文引用的文献
1
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
PLoS Genet. 2011 Sep;7(9):e1002235. doi: 10.1371/journal.pgen.1002235. Epub 2011 Sep 1.
2
Oxidative stress, insulin signaling, and diabetes.
Free Radic Biol Med. 2011 Mar 1;50(5):567-75. doi: 10.1016/j.freeradbiomed.2010.12.006. Epub 2010 Dec 13.
3
Oxidative stress, inflammation, and cancer: how are they linked?
Free Radic Biol Med. 2010 Dec 1;49(11):1603-16. doi: 10.1016/j.freeradbiomed.2010.09.006. Epub 2010 Sep 16.
4
Metals, oxidative stress and neurodegenerative disorders.
Mol Cell Biochem. 2010 Dec;345(1-2):91-104. doi: 10.1007/s11010-010-0563-x. Epub 2010 Aug 22.
5
Stress-activated cap'n'collar transcription factors in aging and human disease.
Sci Signal. 2010 Mar 9;3(112):re3. doi: 10.1126/scisignal.3112re3.
6
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.
Aging Cell. 2009 Sep;8(5):524-41. doi: 10.1111/j.1474-9726.2009.00501.x. Epub 2009 Jul 3.
7
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.
Mol Cell Biol. 2009 May;29(10):2704-15. doi: 10.1128/MCB.01811-08. Epub 2009 Mar 9.
8
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PLoS Biol. 2008 Sep 30;6(9):e233. doi: 10.1371/journal.pbio.0060233.
9
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
Cell. 2008 Mar 21;132(6):1025-38. doi: 10.1016/j.cell.2008.01.030.
10
Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.
PLoS One. 2007 Nov 28;2(11):e1213. doi: 10.1371/journal.pone.0001213.
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