六佳：γδ T 细胞对免疫学的独特贡献。
Six-of-the-best: unique contributions of γδ T cells to immunology.
机构信息
London Research Institute, Cancer Research UK, London WC2A 3LY, UK.
出版信息
Nat Rev Immunol. 2013 Feb;13(2):88-100. doi: 10.1038/nri3384.
γδ T cells are a unique and conserved population of lymphocytes that have been the subject of a recent explosion of interest owing to their essential contributions to many types of immune response and immunopathology. But what does the integration of recent and long-established studies really tell us about these cells and their place in immunology? The time is ripe to consider the evidence for their unique and crucial functions. We conclude that whereas B cells and αβ T cells are commonly thought to contribute primarily to the antigen-specific effector and memory phases of immunity, γδ T cells are distinct in that they combine conventional adaptive features (inherent in their T cell receptors and pleiotropic effector functions) with rapid, innate-like responses that can place them in the initiation phase of immune reactions. This underpins a revised perspective on lymphocyte biology and the regulation of immunogenicity.
γδ T 细胞是一种独特而保守的淋巴细胞群体，由于其对多种类型的免疫反应和免疫病理学的重要贡献，最近引起了人们的极大兴趣。但是，最近和长期确立的研究的综合结果真正告诉了我们这些细胞及其在免疫学中的地位？现在是时候考虑这些细胞独特而关键功能的证据了。我们的结论是，虽然 B 细胞和 αβ T 细胞通常被认为主要有助于免疫的抗原特异性效应和记忆阶段，但 γδ T 细胞的不同之处在于，它们将传统的适应性特征（存在于其 T 细胞受体和多效性效应功能中）与快速的、类似先天的反应相结合，从而使它们处于免疫反应的启动阶段。这为淋巴细胞生物学和免疫原性的调节提供了一个新的视角。
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