汗液钠和氯浓度——成人囊性纤维化诊断的基本标准。

Sweat sodium and chloride concentrations--essential criteria for the diagnosis of cystic fibrosis in adults.

作者信息

Hall S K, Stableforth D E, Green A

机构信息

Clinical Chemistry Department, Children's Hospital, Birmingham, UK.

出版信息

Ann Clin Biochem. 1990 Jul;27 ( Pt 4):318-20. doi: 10.1177/000456329002700406.

DOI:10.1177/000456329002700406

PMID:2403231

Abstract

Criteria for a positive sweat test in children (sweat sodium greater than 60 mmol/L and sweat chloride greater than 70 mmol/L) were investigated in a series of adults aged between 18 and 40 years using the standard Gibson and Cooke technique of pilocarpine iontophoresis. A significant number of non-cystic fibrosis adults had sweat sodium values greater than 60 mmol/L whereas a concentration of chloride greater than 70 mmol/L always discriminated adults with cystic fibrosis from normal adults and those with chest disease not due to cystic fibrosis. In all cases of adult cystic fibrosis the sweat sodium concentration was greater than 80 mmol/L. The Na:Cl ratio and sum of Na and Cl provided additional helpful criteria in distinguishing between adults with and without cystic fibrosis.

摘要

采用标准的毛果芸香碱离子电渗疗法，对一系列年龄在18至40岁之间的成年人进行研究，以探讨儿童汗液试验阳性的标准（汗液钠大于60 mmol/L且汗液氯大于70 mmol/L）。相当数量的非囊性纤维化成年人汗液钠值大于60 mmol/L，而氯浓度大于70 mmol/L总能将囊性纤维化成年人与正常成年人以及非囊性纤维化所致胸部疾病的成年人区分开来。在所有成年囊性纤维化病例中，汗液钠浓度大于80 mmol/L。钠与氯的比值以及钠和氯的总和为区分有无囊性纤维化的成年人提供了额外有用的标准。