从脉冲序列到感知：运用视力恢复技术创造一个感知上可理解的世界所面临的挑战。
Pulse trains to percepts: the challenge of creating a perceptually intelligible world with sight recovery technologies.
作者信息
Fine Ione, Boynton Geoffrey M
机构信息
Department of Psychology, University of Washington, Seattle, WA, USA
Department of Psychology, University of Washington, Seattle, WA, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2015 Sep 19;370(1677):20140208. doi: 10.1098/rstb.2014.0208.
An extraordinary variety of sight recovery therapies are either about to begin clinical trials, have begun clinical trials, or are currently being implanted in patients. However, as yet we have little insight into the perceptual experience likely to be produced by these implants. This review focuses on methodologies, such as optogenetics, small molecule photoswitches and electrical prostheses, which use artificial stimulation of the retina to elicit percepts. For each of these technologies, the interplay between the stimulating technology and the underlying neurophysiology is likely to result in distortions of the perceptual experience. Here, we describe some of these potential distortions and discuss how they might be minimized either through changes in the encoding model or through cortical plasticity.
各种各样的视力恢复疗法即将开始临床试验、已经开始临床试验，或者目前正在植入患者体内。然而，到目前为止，我们对这些植入物可能产生的感知体验了解甚少。本综述聚焦于光遗传学、小分子光开关和电假体等方法，这些方法利用对视网膜的人工刺激来引发感知。对于这些技术中的每一种，刺激技术与潜在神经生理学之间的相互作用可能会导致感知体验的扭曲。在这里，我们描述了其中一些潜在的扭曲，并讨论了如何通过编码模型的改变或通过皮质可塑性将它们最小化。
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