对有丝分裂中着丝粒转录的见解。
Insights into centromeric transcription in mitosis.
作者信息
Liu Hong
机构信息
a Department of Biochemistry and Molecular Biology , Tulane University; School of Medicine , New Orleans , LA , USA.
出版信息
Transcription. 2016;7(1):21-5. doi: 10.1080/21541264.2015.1127315.
Abstract
The major role of RNA polymerase II (RNAP II) is to generate mRNAs. I recently uncovered a novel function of RNAP II in chromosome segregation in mitosis, installing the cohesin protector, Shugoshin, at centromeres. Here I will discuss the current understanding of RNAP II-dependent centromeric transcription in mitosis.
摘要
RNA聚合酶II（RNAP II）的主要作用是生成信使核糖核酸（mRNA）。我最近发现了RNAP II在有丝分裂染色体分离中的一种新功能，即在着丝粒处安装黏连蛋白保护因子Shugoshin。在此，我将讨论目前对有丝分裂中依赖RNAP II的着丝粒转录的理解。
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