Suppr超能文献

社区居住老年人虚弱的流行率和发生率:北京老龄化纵向研究 II。

Prevalence and Incidence of Frailty in Community-Dwelling Older People: Beijing Longitudinal Study of Aging II.

机构信息

Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China.

Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China.

出版信息

J Am Geriatr Soc. 2016 Jun;64(6):1281-6. doi: 10.1111/jgs.14135.

Abstract

OBJECTIVES

To estimate the prevalence and incidence of frailty and evaluate the effect of frailty on adverse outcomes in Chinese elderly adults.

DESIGN

Secondary analysis of prospective cohort study.

SETTING

Community in Beijing, China.

PARTICIPANTS

Individuals aged 55 and older (N = 10,039).

MEASUREMENTS

A Frailty Index (FI) was derived from 34 items using Rockwood's cumulative deficits method. A FI of 0.25 or greater indicated frailty. The clinical outcome was evaluated using a composite variable of any of the following adverse events: falls, hospitalization, activity of daily living disability, and death.

RESULTS

The overall crude prevalence of frailty was 12.3% (95% confidence interval (CI) = 11.7-13.0%), and the standardized prevalence was 9.1% (95% CI = 8.6-9.7%). The crude incidence was 13.0% (95% CI = 12.2-13.9%), and the standardized incidence 10.8% (95% CI = 10.0-11.6%). Prevalence and incidence were significantly greater with age (P for trend < .001) and greater in women (P < .001) and urban residents (P < .001). Participants with lower education and having three or more diseases and taking four or more medications daily were more likely to develop frailty over follow-up (all P < .05). After adjusting for age, number of diseases, and smoking at baseline, the risk of any adverse event in 1 year in the frail group was 58% higher than in the nonfrail group (adjusted odds ratio = 1.58, 95% CI = 1.30-1.93, P < .001).

CONCLUSION

A feasible FI that can be used in routine medical evaluation in a primary care setting was developed, and a 12.3% prevalence and a 13% incidence of frailty was demonstrated in community-dwelling Chinese older adults. Frailty is more common for urban and female residents in the oldest old group. Being frail significantly predicts geriatric adverse outcomes, indicating the importance of early screening and intervention in frail individuals in primary care.

摘要

目的

评估中国老年人衰弱的流行率和发生率,并评估衰弱对不良结局的影响。

设计

前瞻性队列研究的二次分析。

地点

中国北京社区。

参与者

年龄在 55 岁及以上的个体(N=10039)。

测量方法

采用 Rockwood 累积缺陷法,从 34 个项目中得出衰弱指数(FI)。FI 达到或超过 0.25 表示衰弱。临床结局采用以下任何不良事件的综合变量进行评估:跌倒、住院、日常生活活动能力障碍和死亡。

结果

衰弱的总体粗患病率为 12.3%(95%置信区间[CI]为 11.7%至 13.0%),标准化患病率为 9.1%(95%CI为 8.6%至 9.7%)。粗发病率为 13.0%(95%CI为 12.2%至 13.9%),标准化发病率为 10.8%(95%CI为 10.0%至 11.6%)。发病率和患病率随年龄增长显著增加(趋势 P<.001),且女性(P<.001)和城市居民(P<.001)中更高。在随访过程中,教育程度较低、患有三种或三种以上疾病以及每天服用四种或四种以上药物的参与者更容易出现衰弱(均 P<.05)。在校正基线时的年龄、疾病数量和吸烟状况后,衰弱组 1 年内发生任何不良事件的风险比非衰弱组高 58%(调整后的优势比[OR]=1.58,95%CI为 1.30-1.93,P<.001)。

结论

在中国基层医疗机构中,开发了一种可行的 FI,可以用于常规医疗评估,研究显示,在社区居住的中国老年人中,衰弱的患病率为 12.3%,发病率为 13%。在最年长的老年人中,城市和女性居民中衰弱更为常见。衰弱显著预测老年不良结局,表明在基层医疗中对衰弱个体进行早期筛查和干预非常重要。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验