癌症中的SWI/SNF复合物
SWI/SNF complex in cancer.
作者信息
Lu Chao, Allis C David
机构信息
Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, New York, USA.
出版信息
Nat Genet. 2017 Jan 31;49(2):178-179. doi: 10.1038/ng.3779.
Abstract
Four studies in this issue report new mechanisms underlying the function of the chromatin remodeling SWI/SNF complex in controlling gene expression and suppressing tumor development, providing valuable insights into the treatment of cancers harboring mutations in genes encoding SWI/SNF complex subunits.
摘要
本期的四项研究报告了染色质重塑SWI/SNF复合物在控制基因表达和抑制肿瘤发展中发挥作用的新机制，为治疗编码SWI/SNF复合物亚基的基因发生突变的癌症提供了有价值的见解。
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