评估生物膜分散作为恢复抗菌疗效的治疗策略。
Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy.
机构信息
Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore.
Interdisciplinary Graduate School, Nanyang Technological University, Singapore.
出版信息
Antimicrob Agents Chemother. 2017 Sep 22;61(10). doi: 10.1128/AAC.01088-17. Print 2017 Oct.
Abstract
As a proof-of-concept study, the direct impact of biofilm dispersal on the efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the engineered strain PAO1/p - resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.
摘要
作为概念验证研究，评估了生物膜分散对亚胺培南和妥布霉素疗效的直接影响，针对阿拉伯糖诱导的生物膜进行了为期 3 天的实验，通过激活工程菌株 PAO1/p 中的磷酸二酯酶 YhjH 来实现生物膜分散，结果导致抗菌药物疗效提高和亚胺培南-妥布霉素联合用药的协同作用增强。这些结果支持使用生物膜分散来增强治疗生物膜相关感染的抗菌药物疗效，这是一种有前途的治疗策略。
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