迁移至肿瘤：T细胞的路线图

Migrating into the Tumor: a Roadmap for T Cells.

作者信息

van der Woude Lieke L, Gorris Mark A J, Halilovic Altuna, Figdor Carl G, de Vries I Jolanda M

机构信息

Department of Tumor Immunology, Radboud Institute of Molecular Life Sciences, Geert Grooteplein 26-28, 6525 GA, Nijmegen, The Netherlands; Department of Pathology, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands; Joint first authors.

Department of Tumor Immunology, Radboud Institute of Molecular Life Sciences, Geert Grooteplein 26-28, 6525 GA, Nijmegen, The Netherlands; Joint first authors.

出版信息

Trends Cancer. 2017 Nov;3(11):797-808. doi: 10.1016/j.trecan.2017.09.006. Epub 2017 Nov 6.

DOI:10.1016/j.trecan.2017.09.006

PMID:29120755

Abstract

Tumors can be divided into 'hot' (T cell inflamed) or 'cold' (T cell noninflamed) according to the presence of immune cells. In this review, we discuss variables that influence T cell migration into the tumor microenvironment. Chemokines can attract T cells to the tumor site and tumor intrinsic pathways can influence the composition of local chemokines. Tumor-induced vasculature can hamper T cell migration. Other immune cells and tumor-derived molecules can block T cell proliferation and survival. It is important to better understand these mechanisms in order to target them therapeutically. Enhancing T cell infiltration may increase response rates to immunotherapy and increase survival.

摘要

根据免疫细胞的存在情况，肿瘤可分为“热”（T细胞炎症性）或“冷”（T细胞非炎症性）。在本综述中，我们讨论影响T细胞迁移至肿瘤微环境的各种因素。趋化因子可将T细胞吸引至肿瘤部位，而肿瘤内在途径可影响局部趋化因子的组成。肿瘤诱导的脉管系统会阻碍T细胞迁移。其他免疫细胞和肿瘤衍生分子可阻断T细胞增殖和存活。为了进行靶向治疗，更好地理解这些机制非常重要。增强T细胞浸润可能会提高免疫治疗的反应率并延长生存期。