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术前吸烟以及使用麻醉性镇痛药、苯二氮䓬类药物和曲马多是髋关节和膝关节置换术后使用麻醉性镇痛药的危险因素。

Preoperative Smoking and Narcotic, Benzodiazepine, and Tramadol Use are Risk Factors for Narcotic Use After Hip and Knee Arthroplasty.

机构信息

Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

出版信息

J Arthroplasty. 2018 Sep;33(9):2774-2779. doi: 10.1016/j.arth.2018.03.066. Epub 2018 Apr 9.

Abstract

BACKGROUND

The use of narcotics has been found to be a modifiable risk factor for success of arthroplasty. We sought to determine the risk factors leading to increased narcotic use after total hip arthroplasty and total knee arthroplasty.

METHODS

A retrospective chart review was performed on new patients presenting to an orthopedic reconstructive-service clinic. New patients aged 18 years or older with osteoarthritis of the hip or knee who presented over a 1-year period and underwent total knee arthroplasty or total hip arthroplasty were included. The Arkansas prescription monitoring program was then used to determine recent narcotic and benzodiazepine prescriptions filled within 3 months of surgery, and this was converted into morphine milligram equivalents (MME).

RESULTS

One hundred seventy-nine patients met the inclusion criteria. When compared with patients who did not take any preoperative opioids, narcotic- and tramadol-only users filled an average of 86% and 38% more MME, respectively. Benzodiazepine users required an average of 81% more MME postoperative than nonusers, and smokers required an average of 90% more MME postoperative than nonsmokers. Subjects with body mass index >40 kg/m had 82% higher average postoperative MME than subjects with body mass index <25 kg/m. Age and sex had no significant correlation with postoperative narcotic use.

CONCLUSION

This study suggests that a patient's preoperative narcotic, tramadol, benzodiazepine, and tobacco use are correlated to the amount of postoperative narcotic prescriptions filled in the 3 months following surgery. Predisposition to substance abuse may be a characteristic which leads to increased postoperative narcotic use.

摘要

背景

已发现使用麻醉剂是关节成形术成功的一个可改变的风险因素。我们旨在确定导致全髋关节置换术和全膝关节置换术后麻醉剂使用增加的风险因素。

方法

对在矫形重建服务诊所就诊的新患者进行回顾性图表审查。纳入在 1 年内出现髋关节或膝关节骨关节炎且接受全膝关节置换术或全髋关节置换术的年龄在 18 岁及以上的新患者。然后使用阿肯色州处方监测计划来确定手术前 3 个月内最近开具的麻醉剂和苯二氮䓬类药物的处方,并将其转换为吗啡毫克当量(MME)。

结果

179 名患者符合纳入标准。与未服用任何术前阿片类药物的患者相比,仅使用麻醉剂和曲马多的患者分别平均多服用 86%和 38%的 MME。术后苯二氮䓬类药物使用者比非使用者平均多服用 81%的 MME,吸烟者比不吸烟者平均多服用 90%的 MME。体重指数(BMI)>40 kg/m2的患者术后平均 MME 比 BMI<25 kg/m2的患者高 82%。年龄和性别与术后使用麻醉剂无显著相关性。

结论

本研究表明,患者术前使用麻醉剂、曲马多、苯二氮䓬类药物和吸烟与术后 3 个月内服用的麻醉剂处方量相关。物质滥用的倾向可能是导致术后麻醉剂使用增加的特征。

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