近红外荧光探针用于活细胞和体内 Cu 的选择性检测。
Near-infrared fluorescent probe for selective detection of Cu in living cells and in Vivo.
机构信息
School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Taian, Shandong 271016, PR China.
School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Taian, Shandong 271016, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jun 5;216:404-410. doi: 10.1016/j.saa.2019.03.062. Epub 2019 Mar 19.
A NIR-rhodamine fluorescent probe was designed and successfully synthesized. The structure of the probe NRh-Cu was characterized by H NMR, C NMR and HRMS. The probe was found to show high sensitivity and high selectivity. The detection limit was calculated to be as low as 0.95 ppb. The sensing mechanism was proposed and confirmed by HRMS spectra. Furthermore, it could be used for imaging Cu in living cells and in vivo.
设计并成功合成了一种近红外-罗丹明荧光探针。探针 NRh-Cu 的结构通过 1H NMR、13C NMR 和高分辨质谱（HRMS）进行了表征。该探针表现出高灵敏度和高选择性。检测限计算低至 0.95 ppb。通过高分辨质谱（HRMS）谱图提出并证实了传感机制。此外，它还可用于活细胞和体内的 Cu 成像。
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