用于 Fe(III) 的席夫碱基荧光增强探针及其在癌细胞中的传感应用。
A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells.
机构信息
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Department of Chemistry, Korea University, Seoul 02841, Korea.
出版信息
Sensors (Basel). 2019 May 31;19(11):2500. doi: 10.3390/s19112500.
We report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(III) in a HeLa cancer cell line, with very low cytotoxicity. As a new bio-imaging probe for Fe(III), it gave bright fluorescent images in confocal laser scanning microscopy (CLSM).
我们报告了一种新的席夫碱荧光探针，它可以检测三价铁离子（Fe(III)），并产生显著的荧光增强响应。该探针在水相介质中对 Fe(III)具有高灵敏度（0.8 ppb）和快速的响应时间（<10 s）。此外，该探针还表现出在 HeLa 癌细胞系中检测 Fe(III)的能力，具有非常低的细胞毒性。作为一种新的生物成像探针用于 Fe(III)，它在共聚焦激光扫描显微镜（CLSM）中给出了明亮的荧光图像。
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