解除 53BP1 的 DSB 末端保护和 CSR 促进功能。
Uncoupling the DSB End-Protecting and CSR-Promoting Functions of 53BP1.
机构信息
Immunology Program, Memorial Sloan Kettering Cancer Center, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, USA.
Immunology Program, Memorial Sloan Kettering Cancer Center, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, USA.
出版信息
Cell Rep. 2019 Aug 6;28(6):1387-1388. doi: 10.1016/j.celrep.2019.07.076.
PMID:31390553
Abstract
Sundaravinayagam et al. (2019) uncovered a critical role of 53BP1 in class switch recombination in B cells beyond its role in limiting end resection.
摘要
Sundaravinayagam 等人（2019 年）揭示了 53BP1 在 B 细胞类别转换重组中的关键作用，超出了其在限制末端切除中的作用。
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