SLC17A9 高表达与胃癌患者的不良预后相关。
High SLC17A9 expression correlates with poor survival in gastric carcinoma.
机构信息
Digestive Medicine Centre, Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen 518000, PR China.
Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou 510080, PR China.
出版信息
Future Oncol. 2019 Dec;15(36):4155-4166. doi: 10.2217/fon-2019-0283. Epub 2019 Dec 4.
To elucidate the clinicopathological significance and prognostic value of SLC17A9 expression in gastric carcinoma (GC). mRNA level and its relationship with mutation was analyzed. SLC17A9 protein expression was examined by immunohistochemistry in 161 patients. mRNA and protein expression were higher in GC tissues than in adjacent normal tissues (p < 0.01). mRNA expression was higher in GC tissues having mutated than in tissues with wild-type (p < 0.001). High SLC17A9 expression was also significantly associated with poor overall survival and recurrence-free survival and was also found to be an independent prognostic factor for long-term survival in GC patients. Our results show that SLC17A9 may serve as a potential prognostic biomarker in GC patients.
为了阐明 SLC17A9 在胃癌（GC）中的表达的临床病理意义和预后价值。分析了 SLC17A9 的 mRNA 水平及其与 突变的关系。采用免疫组织化学法检测 161 例患者中 SLC17A9 蛋白的表达。SLC17A9 的 mRNA 和蛋白表达在 GC 组织中均高于相邻正常组织（p<0.01）。在有 突变的 GC 组织中 SLC17A9 的 mRNA 表达高于有野生型 的组织（p<0.001）。高 SLC17A9 表达与总生存和无复发生存不良显著相关，并且是 GC 患者长期生存的独立预后因素。我们的研究结果表明，SLC17A9 可能作为 GC 患者的一个潜在的预后生物标志物。
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