豚草提取物对 DNCB 诱导的小鼠特应性皮炎模型的抑制作用。
Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Extract.
机构信息
College of Pharmacy, Pusan National University, Busan 46241, Korea.
Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea.
出版信息
Nutrients. 2020 Jan 8;12(1):173. doi: 10.3390/nu12010173.
(L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a concentration of 1%. Furthermore, also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that has potential as a topical treatment for AD and as an adjunctive agent to control AD.
（拉丁名）C.A. Mey. 在传统中医中用于治疗关节炎和支气管炎等炎症性疾病。在这项研究中，我们旨在研究 2,4-二硝基氯苯（DNCB）诱导的特应性皮炎（AD）小鼠皮肤炎症的乙醇提取物的作用。将 的乙醇提取物局部应用于患有皮炎的 DNCB 敏化无毛小鼠，持续两周，可减少红斑、鳞屑和水肿。在 1%浓度下，皮肤水合作用得到改善，经表皮水分流失减少。此外， 还显著降低了我们的小鼠模型中的血清 IgE 和 IL-4 浓度。这些结果表明， 作为 AD 的局部治疗药物和控制 AD 的辅助剂具有潜力。
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