一项保湿剂疗法用于特应性皮炎一级预防的初步研究。
A pilot study of emollient therapy for the primary prevention of atopic dermatitis.
机构信息
Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239-4501, USA.
出版信息
J Am Acad Dermatol. 2010 Oct;63(4):587-93. doi: 10.1016/j.jaad.2009.11.011. Epub 2010 Aug 7.
BACKGROUND
Prevention strategies in atopic dermatitis (AD) using allergen avoidance have not been consistently effective. New research reveals the importance of the skin barrier in the development of AD and possibly food allergy and asthma. Correcting skin barrier defects from birth may prevent AD onset or moderate disease severity.
OBJECTIVE
We sought to determine the feasibility of skin barrier protection as a novel AD prevention strategy.
METHODS
We enrolled 22 neonates at high risk for developing AD in a feasibility pilot study using emollient therapy from birth.
RESULTS
No intervention-related adverse events occurred in our cohort followed up for a mean time of 547 days. Of the 20 subjects who remained in the study, 3 (15.0%) developed AD, suggesting a protective effect when compared with historical controls. Skin barrier measurements remained within ranges seen in normal-appearing skin.
LIMITATIONS
No conclusions regarding efficacy can be made without a control group.
CONCLUSIONS
Skin barrier repair from birth represents a novel and feasible approach to AD prevention. Further studies are warranted to determine the efficacy of this approach.
背景
在特应性皮炎（AD）中使用过敏原回避的预防策略并没有始终有效。新的研究揭示了皮肤屏障在 AD 以及可能的食物过敏和哮喘发展中的重要性。从出生开始纠正皮肤屏障缺陷可能预防 AD 的发病或减轻疾病严重程度。
目的
我们旨在确定皮肤屏障保护作为一种新型 AD 预防策略的可行性。
方法
我们对 22 名具有发生 AD 高风险的新生儿进行了一项使用保湿剂治疗的可行性试点研究。
结果
在随访平均 547 天的时间里，我们的队列中没有发生与干预相关的不良事件。在 20 名仍在研究中的受试者中，有 3 名（15.0%）发生了 AD，与历史对照相比，这表明有保护作用。皮肤屏障测量值仍在正常外观皮肤的范围内。
局限性
没有对照组，因此无法得出关于疗效的结论。
结论
从出生开始修复皮肤屏障代表了一种新颖且可行的 AD 预防方法。需要进一步的研究来确定这种方法的疗效。
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