鲍曼不动杆菌中抗菌肽 LL-37（一种抗菌肽）诱导的多粘菌素依赖性。
Cathelicidin LL-37 (an antimicrobial peptide)-induced colistin dependence in Acinetobacter baumannii.
机构信息
Division of Antimicrobial Resistance, Korea Centers for Disease Control and Prevention, Cheongju 28159, South Korea.
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, South Korea.
出版信息
Diagn Microbiol Infect Dis. 2020 Apr;96(4):114965. doi: 10.1016/j.diagmicrobio.2019.114965. Epub 2019 Dec 30.
Abstract
In this study, we demonstrated the development of colistin dependence in Acinetobacter baumannii isolates after exposure to the human cationic antimicrobial peptide LL-37. The LL-37-induced colistin-dependent mutants showed susceptibility to many other antibiotics and IS1595 or ATTT insertions in LpxACD.
摘要
在这项研究中，我们证明了在接触人阳离子抗菌肽 LL-37 后，鲍曼不动杆菌分离株中出现了粘菌素依赖性的发展。LL-37 诱导的粘菌素依赖性突变体对许多其他抗生素和 LpxACD 中的 IS1595 或 ATTT 插入敏感。
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