cullin-5的功能与特性，一种癌症的潜在治疗靶点。
The functions and properties of cullin-5, a potential therapeutic target for cancers.
作者信息
Gao Feng, Fan Yimin, Zhou Bolun, Guo Weihua, Jiang Xingjun, Shi Jing, Ren Caiping
机构信息
Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University 87 Xiangya Road, Kaifu District, Changsha 410008, China.
Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, School of Basic Medical Science, Central South University Changsha, Hunan, China.
出版信息
Am J Transl Res. 2020 Feb 15;12(2):618-632. eCollection 2020.
Abstract
Cullin-5 (CUL5), a scaffold protein in active cullin-RING ubiquitin ligase (CRL) complexes, is a member of the cullin family of proteins. The CUL5-type ubiquitin ligase can target multiple proteins involved in ubiquitination and proteasome degradation. CUL5 plays positive roles in regulating cell growth, proliferation and physiological and other processes in the human body. It has been found that the expression of CUL5 is significantly downregulated in various cancer cells, which affects the course of the cancers. Here, we reviewed the current data on the expression and role of CUL5 in both normal and cancer cells, its possible mechanisms, and its potential as a therapeutic target for cancers.
摘要
Cullin-5（CUL5）是活性cullin-RING泛素连接酶（CRL）复合物中的一种支架蛋白，是cullin蛋白家族的成员。CUL5型泛素连接酶可以靶向多种参与泛素化和蛋白酶体降解的蛋白质。CUL5在调节细胞生长、增殖以及人体生理等过程中发挥着积极作用。研究发现，CUL5在各种癌细胞中的表达显著下调，这影响了癌症的进程。在此，我们综述了目前关于CUL5在正常细胞和癌细胞中的表达及作用、其可能的机制以及其作为癌症治疗靶点的潜力的相关数据。
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