免疫衰老与年龄相关疾病之间的相互作用。
The interplay between immunosenescence and age-related diseases.
作者信息
Barbé-Tuana Florencia, Funchal Giselle, Schmitz Carine Raquel Richter, Maurmann Rafael Moura, Bauer Moisés E
机构信息
Laboratory of Immunobiology, Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Graduate Program in Cell Biology: Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
出版信息
Semin Immunopathol. 2020 Oct;42(5):545-557. doi: 10.1007/s00281-020-00806-z. Epub 2020 Aug 3.
The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases.
衰老的免疫系统（免疫衰老）与老年人发病率和死亡率的增加有关。值得注意的是，T细胞衰老和低度炎症（炎症衰老）与多种年龄相关疾病有关。晚期分化T细胞（CD28）、调节性T细胞的扩增、自身抗体血清水平升高以及促炎细胞因子与衰老过程中的疾病有关。在患有慢性炎症性疾病（如类风湿性关节炎）的成年人中可以识别出加速免疫衰老的特征，并且这些特征可预测不良临床结果。因此，免疫衰老与年龄相关疾病之间存在相互作用。在本综述中，我们讨论衰老的免疫系统如何可能促进神经退行性疾病、类风湿性关节炎、癌症、心血管疾病和代谢疾病等年龄相关疾病的发生发展和临床病程。
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