Shiau Stephanie, Bender Alexis A, O'Halloran Jane A, Sundermann Erin, Aggarwal Juhi, Althoff Keri N, Baker Jason V, Deeks Steven, Fried Linda P, Karpiak Stephen, Karris Maile Y, Marcotte Thomas D, Nachega Jean B, Margolick Joseph B, Erlandson Kristine M, Moore David J
Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA.
Division of General Medicine and Geriatrics, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
AIDS Res Hum Retroviruses. 2020 Dec;36(12):973-981. doi: 10.1089/AID.2020.0128. Epub 2020 Sep 23.
With increasing effectiveness of antiretroviral therapy, people with HIV (PWH) are living longer and the prevalence of older PWH continues to increase. Accordingly, PWH are experiencing an increased burden of age-related comorbidities. With this shifting demographics, clinicians and researchers face additional challenges in how to identify, address, and manage the complex intersections of HIV- and aging-related conditions. Established in 2009, the International Workshop on HIV and Aging brings together clinicians and researchers in cross-disciplinary fields along with community advocates and PWH to address the multidisciplinary nature of HIV and aging. This article summarizes plenary talks from the 10th Annual International Workshop on HIV and Aging, which took place in New York City on October 10 and 11, 2019. Presentation topics included the following: the burdens of HIV-associated comorbidities, aging phenotypes, community engagement, and loneliness; these issues are especially important for older PWH, considering the current COVID-19 pandemic. We also discuss broad questions and potential directions for future research necessary to better understand the interaction between HIV and aging.
随着抗逆转录病毒疗法有效性的提高,艾滋病病毒感染者(PWH)的寿命延长,老年艾滋病病毒感染者的患病率持续上升。因此,艾滋病病毒感染者面临着与年龄相关的合并症负担增加的问题。随着这一人口结构的变化,临床医生和研究人员在如何识别、应对和管理与艾滋病病毒及衰老相关疾病的复杂交叉问题上面临着额外的挑战。2009年成立的国际艾滋病病毒与衰老研讨会将跨学科领域的临床医生和研究人员以及社区倡导者和艾滋病病毒感染者聚集在一起,以应对艾滋病病毒与衰老的多学科性质。本文总结了2019年10月10日至11日在纽约市举行的第10届艾滋病病毒与衰老年度国际研讨会的全会报告。演讲主题包括:与艾滋病病毒相关的合并症负担、衰老表型、社区参与和孤独感;考虑到当前的新冠疫情,这些问题对老年艾滋病病毒感染者尤为重要。我们还讨论了为更好地理解艾滋病病毒与衰老之间的相互作用而进行未来研究所需的广泛问题和潜在方向。