解析健康和疾病状态下的肾素细胞身份。
Deciphering the Identity of Renin Cells in Health and Disease.
机构信息
Department of Biology, University of Virginia, Charlottesville, VA, USA; Department of Pediatrics, University of Virginia, Charlottesville, VA, USA; Child Health Research Center, University of Virginia, Charlottesville, VA, USA.
Department of Pediatrics, University of Virginia, Charlottesville, VA, USA; Child Health Research Center, University of Virginia, Charlottesville, VA, USA.
出版信息
Trends Mol Med. 2021 Mar;27(3):280-292. doi: 10.1016/j.molmed.2020.10.003. Epub 2020 Nov 5.
Hypotension and changes in fluid-electrolyte balance pose immediate threats to survival. Juxtaglomerular cells respond to such threats by increasing the synthesis and secretion of renin. In addition, smooth muscle cells (SMCs) along the renal arterioles transform into renin cells until homeostasis has been regained. However, chronic unrelenting stimulation of renin cells leads to severe kidney damage. Here, we discuss the origin, distribution, function, and plasticity of renin cells within the kidney and immune compartments and the consequences of distorting the renin program. Understanding how chronic stimulation of these cells in the context of hypertension may lead to vascular pathology will serve as a foundation for targeted molecular therapies.
低血压和液体-电解质平衡的变化对生存构成直接威胁。球旁细胞对这些威胁的反应是增加肾素的合成和分泌。此外，肾小动脉平滑肌细胞（SMCs）会转化为肾素细胞，直到恢复体内平衡。然而，肾素细胞的慢性持续刺激会导致严重的肾脏损伤。在这里，我们讨论了肾素细胞在肾脏和免疫组织中的起源、分布、功能和可塑性，以及扭曲肾素程序的后果。了解高血压背景下这些细胞的慢性刺激如何导致血管病理学，将为靶向分子治疗奠定基础。
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