近红外吸收的苯并菲稠合 BODIPY J-聚集体作为一种高效光热纳米试剂。

Near-IR absorbing J-aggregates of a phenanthrene-fused BODIPY as a highly efficient photothermal nanoagent.

机构信息

The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, China.

出版信息

Chem Commun (Camb). 2020 Nov 24;56(93):14709-14712. doi: 10.1039/d0cc06014c.

DOI:10.1039/d0cc06014c

PMID:33174551

Abstract

A phenanthrene-[b]-fused BODIPY exhibited well-defined J-aggregation behavior in both pure hydrocarbon solution and aqueous solution. The highly stable J-aggregates showed narrowed and largely red-shifted absorption with λmax of 840 nm and enhanced molar absorption coefficients (271 000 M-1 cm-1). Encapsulation of J-aggregates within a micellar nanocapsule resulted in nanoparticles that demonstrated good biocompatibility, excellent photothermal stability, high photothermal conversion ability (η ∼ 46.9%) and an effective phototoxicity (IC50 ∼ 2 μg mL-1 in HeLa cells) under 808 nm laser irradiation.

摘要

一种菲并[B]二吡咯亚甲基染料在纯碳氢化合物溶液和水溶液中均表现出明确的 J-聚集行为。高度稳定的 J-聚集体表现出较窄且显著红移的吸收，λmax 为 840nm，摩尔吸收系数增强（271000M-1cm-1）。将 J-聚集体包封在胶束纳米胶囊内得到的纳米颗粒在 808nm 激光照射下表现出良好的生物相容性、优异的光热稳定性、高光热转换能力（η∼46.9%）和有效的光毒性（在 HeLa 细胞中 IC50∼2μgmL-1）。