在 COVID-19 大流行期间探索 N95 过滤式面罩呼吸器 (N95-FFR) 再处理的选择：系统评价。
Exploring options for reprocessing of N95 Filtering Facepiece Respirators (N95-FFRs) amidst COVID-19 pandemic: A systematic review.
机构信息
Department of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
出版信息
PLoS One. 2020 Nov 20;15(11):e0242474. doi: 10.1371/journal.pone.0242474. eCollection 2020.
BACKGROUND
There is global shortage of Personal Protective Equipment due to COVID-19 pandemic. N95 Filtering Facepiece Respirators (N95-FFRs) provide respiratory protection against respiratory pathogens including SARS-CoV-2. There is scant literature on reprocessing methods which can enable reuse of N95-FFRs.
AIM
We conducted this study to evaluate research done, prior to COVID-19 pandemic, on various decontamination methods for reprocessing of N95-FFRs.
METHODS
We searched 5 electronic databases (Pubmed, Google Scholar, Crossref, Ovid, ScienceDirect) and 1 Grey literature database (OpenGrey). We included original studies, published prior to year 2020, which had evaluated any decontamination method on FFRs. Studies had evaluated a reprocessing method against parameters namely physical changes, user acceptability, respirator fit, filter efficiency, microbicidal efficacy and presence of chemical residues post-reprocessing.
FINDINGS AND CONCLUSIONS
Overall, we found 7887 records amongst which 17 original research articles were finally included for qualitative analysis. Overall, 21 different types of decontamination or reprocessing methods for N95-FFRs were evaluated. Most commonly evaluated method for reprocessing of FFRs was Ultraviolet (Type-C) irradiation (UVGI) which was evaluated in 13/17 (76%) studies. We found published literature was scant on this topic despite warning signs of pandemic of a respiratory illness over the years. Promising technologies requiring expeditious evaluation are UVGI, Microwave generated steam (MGS) and based on Hydrogen peroxide vapor. Global presence of technologies, which have been given Emergency use authorisation for N95-FFR reprocessing, is extremely limited. Reprocessing of N95-FFRs by MGS should be considered for emergency implementation in resource limited settings to tackle shortage of N95-FFRs.
SYSTEMATIC REVIEW IDENTIFIER
PROSPERO, PROSPERO ID: CRD42020189684, (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020189684).
背景
由于 COVID-19 大流行，个人防护设备全球短缺。N95 过滤式面罩呼吸器（N95-FFR）可提供针对包括 SARS-CoV-2 在内的呼吸道病原体的呼吸保护。关于可重复使用 N95-FFR 的再处理方法的文献很少。
目的
我们进行这项研究是为了评估 COVID-19 大流行之前针对 N95-FFR 再处理的各种消毒方法所做的研究。
方法
我们搜索了 5 个电子数据库（Pubmed、Google Scholar、Crossref、Ovid、ScienceDirect）和 1 个灰色文献数据库（OpenGrey）。我们纳入了发表于 2020 年之前的原始研究，这些研究评估了 FFR 上的任何消毒方法。研究评估了再处理方法针对物理变化、使用者可接受性、口罩贴合度、过滤效率、杀菌效果和再处理后是否存在化学残留物等参数。
结果与结论
总体而言，我们在 7887 条记录中发现了 17 篇最终用于定性分析的原始研究文章。总体而言，评估了 N95-FFR 的 21 种不同类型的消毒或再处理方法。最常评估的 FFR 再处理方法是紫外线（C 型）照射（UVGI），在 17 项研究中有 13 项（76%）进行了评估。我们发现，尽管多年来呼吸道疾病大流行的警告信号不断，但关于这个主题的文献却很少。需要迅速评估的有前途的技术是紫外线照射、微波产生的蒸汽（MGS）和基于过氧化氢蒸气的技术。已获得 N95-FFR 再处理紧急使用授权的技术在全球范围内的可用性极为有限。在资源有限的环境中，应考虑使用 MGS 对 N95-FFR 进行再处理，以解决 N95-FFR 的短缺问题。
系统评价标识符
PROSPERO，PROSPERO ID：CRD42020189684，（https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020189684）。
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