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一名患有克罗恩病的青少年的原发性皮肤诺卡菌病

Primary Cutaneous Nocardiosis in an Adolescent with Crohn Disease.

作者信息

Svoboda Steven A, Eikenberg Joshua D

机构信息

Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.

Section of Dermatology, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.

出版信息

Case Rep Pediatr. 2020 Nov 10;2020:1532875. doi: 10.1155/2020/1532875. eCollection 2020.

Abstract

is an aerobic, Gram-positive, partially acid-fast bacterium that often manifests as pulmonary infection since the primary route of entry is via the respiratory tract. As an opportunistic organism, primarily affects immunocompromised individuals. Infection with is uncommon. Primary cutaneous nocardiosis which is caused by percutaneous inoculation is even more rare. Here, we report a case of primary cutaneous nocardiosis in an adolescent with Crohn disease receiving treatment with adalimumab and azathioprine. Early identification and treatment are important to prevent disease progression and to avoid severe complications. Diagnosis is made principally by culture. Given that culture results may take up to two weeks to return, primary cutaneous nocardiosis should be maintained in the differential for any superficial cutaneous infection that arises in individuals undergoing treatment with immunosuppressive agents.

摘要

是一种需氧的革兰氏阳性、部分抗酸菌,由于其主要进入途径是通过呼吸道,常表现为肺部感染。作为一种机会性致病菌,主要影响免疫功能低下的个体。感染并不常见。由经皮接种引起的原发性皮肤诺卡菌病更为罕见。在此,我们报告一例患有克罗恩病的青少年在用阿达木单抗和硫唑嘌呤治疗期间发生原发性皮肤诺卡菌病的病例。早期识别和治疗对于预防疾病进展和避免严重并发症很重要。诊断主要通过培养进行。鉴于培养结果可能需要长达两周才能得出,对于接受免疫抑制剂治疗的个体出现的任何浅表皮肤感染,原发性皮肤诺卡菌病都应保留在鉴别诊断范围内。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3cf/7673915/0f571b01e154/CRIPE2020-1532875.001.jpg

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