长链非编码 RNA H19——肝脏疾病发病机制中的新角色。
Long noncoding RNA H19 - a new player in the pathogenesis of liver diseases.
机构信息
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
出版信息
Transl Res. 2021 Apr;230:139-150. doi: 10.1016/j.trsl.2020.11.010. Epub 2020 Nov 20.
The liver is a vital organ that controls glucose and lipid metabolism, hormone regulation, and bile secretion. Liver injury can occur from various insults such as viruses, metabolic diseases, and alcohol, which lead to acute and chronic liver diseases. Recent studies have demonstrated the implications of long noncoding RNAs (lncRNAs) in the pathogenesis of liver diseases. These newly discovered lncRNAs have various functions attributing to many cellular biological processes via distinct and diverse mechanisms. LncRNA H19, one of the first lncRNAs being identified, is highly expressed in fetal liver but not in adult normal liver. Its expression, however, is increased in liver diseases with various etiologies. In this review, we focused on the roles of H19 in the pathogenesis of liver diseases. This comprehensive review is aimed to provide useful perspectives and translational applications of H19 as a potential therapeutic target of liver diseases.
肝脏是一个重要的器官，控制着葡萄糖和脂质代谢、激素调节和胆汁分泌。肝脏损伤可由病毒、代谢疾病和酒精等各种因素引起，导致急性和慢性肝病。最近的研究表明，长链非编码 RNA（lncRNA）在肝病的发病机制中具有重要意义。这些新发现的 lncRNA 具有多种功能，通过不同的机制参与许多细胞生物学过程。H19 是最早被鉴定的 lncRNA 之一，在胎儿肝脏中高度表达，但在成人正常肝脏中不表达。然而，在具有不同病因的肝脏疾病中，其表达增加。在这篇综述中，我们重点介绍了 H19 在肝病发病机制中的作用。本综述旨在为 H19 作为肝脏疾病潜在治疗靶点提供有用的观点和转化应用。
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