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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.

作者信息

Lei Yuyang, Zhang Jiao, Schiavon Cara R, He Ming, Chen Lili, Shen Hui, Zhang Yichi, Yin Qian, Cho Yoshitake, Andrade Leonardo, Shadel Gerald S, Hepokoski Mark, Lei Ting, Wang Hongliang, Zhang Jin, Yuan Jason X-J, Malhotra Atul, Manor Uri, Wang Shengpeng, Yuan Zu-Yi, Shyy John Y-J

机构信息

Cardiology, First Affiliated Hospital of Xi'an Jiaotong University (Y.L., Jiao Zhang, Z.-Y.Y.).

Cardiovascular Research Center, School of Basic Medical Sciences (Y.L., Jiao Zhang, L.C., Q.Y., S.W.).

出版信息

Circ Res. 2021 Apr 30;128(9):1323-1326. doi: 10.1161/CIRCRESAHA.121.318902. Epub 2021 Mar 31.

Abstract
摘要

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本文引用的文献

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MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.
Circulation. 2020 Sep 22;142(12):1190-1204. doi: 10.1161/CIRCULATIONAHA.120.048191. Epub 2020 Jul 28.
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Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
Cell Metab. 2020 Sep 1;32(3):437-446.e5. doi: 10.1016/j.cmet.2020.07.007. Epub 2020 Jul 17.
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COVID-19: the vasculature unleashed.
Nat Rev Immunol. 2020 Jul;20(7):389-391. doi: 10.1038/s41577-020-0343-0.
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Endothelial cell infection and endotheliitis in COVID-19.
Lancet. 2020 May 2;395(10234):1417-1418. doi: 10.1016/S0140-6736(20)30937-5. Epub 2020 Apr 21.
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10.

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