将 YTH 结构域与癌症联系起来：YTH 家族蛋白在表观遗传学中的重要性。
Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics.
机构信息
Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Cancer Center, Zhejiang University, Hangzhou, China.
Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China.
出版信息
Cell Death Dis. 2021 Apr 1;12(4):346. doi: 10.1038/s41419-021-03625-8.
N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main "readers" of m6A modification. YTH family proteins perform different functions to determine the metabolic fate of m6A-modified RNA. The crystal structure of the YTH domain has been completely resolved, highlighting the important roles of several conserved residues of the YTH domain in the specific recognition of m6A-modified RNAs. Upstream and downstream targets have been successively revealed in different cancer types and the role of YTH family proteins has been emphasized in m6A research. This review describes the regulation of RNAs by YTH family proteins, the structural features of the YTH domain, and the connections of YTH family proteins with human cancers.
N6-甲基腺苷（m6A）是哺乳动物细胞中 mRNA 上最普遍和最可逆转的修饰，最近在表观遗传调控中得到了广泛研究。YTH 家族蛋白的 YTH 结构域可以识别和结合含有 m6A 的 RNA，是 m6A 修饰的主要“读取器”。YTH 家族蛋白通过执行不同的功能来决定 m6A 修饰 RNA 的代谢命运。YTH 结构域的晶体结构已被完全解析，突出了几个保守残基在 m6A 修饰 RNA 特异性识别中的重要作用。在不同的癌症类型中，相继揭示了上游和下游靶标，并且强调了 YTH 家族蛋白在 m6A 研究中的作用。本综述描述了 YTH 家族蛋白对 RNA 的调控、YTH 结构域的结构特征以及 YTH 家族蛋白与人类癌症的联系。
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