体外冲击波疗法促进兔骨质疏松模型中成骨分化。
Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model.
机构信息
Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Orthopaedics, General Hospital of Southern Theater Command of PLA, Guangdong Key Lab of Orthopedic Technology and Implant Materials, Guangzhou, China.
出版信息
Front Endocrinol (Lausanne). 2021 Mar 25;12:627718. doi: 10.3389/fendo.2021.627718. eCollection 2021.
Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation . Local ESW treatment of femur increased bone formation . Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway.
体外冲击波疗法 (ESWT) 已被确定可加速骨形成。然而，其详细机制尚未完全阐明。在这项研究中，我们发现 ESWT 可促进成骨细胞的形成。股骨局部 ESW 治疗可增加骨形成。此外，改变能量的密度或频率，成骨分化没有统计学差异。在兔骨质疏松模型中，局部 ESW 治疗可缓解骨质流失，增加骨小梁数量，并促进 SMAD2 蛋白表达的内源性水平。因此，ESWT 可能通过 TGF-β/SMAD2 通路促进成骨细胞成熟而成为一种有潜力的治疗方法。
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