内分泌干扰化学物质与女性、男性及动物模型中的生殖紊乱
Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.
作者信息
Laws Mary Jo, Neff Alison M, Brehm Emily, Warner Genoa R, Flaws Jodi A
机构信息
Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
出版信息
Adv Pharmacol. 2021;92:151-190. doi: 10.1016/bs.apha.2021.03.008. Epub 2021 May 3.
Abstract
This chapter covers the known effects of endocrine disrupting chemicals (EDCs) on reproductive disorders. The EDCs represented are highly studied, including plasticizers (bisphenols and phthalates), chemicals in personal care products (parabens), persistent environmental contaminants (polychlorinated biphenyls), and chemicals in pesticides or herbicides. Both female and male reproductive disorders are reviewed in the chapter. Female disorders include infertility/subfertility, irregular reproductive cycles, early menopause, premature ovarian insufficiency, polycystic ovarian syndrome, endometriosis, and uterine fibroids. Male disorders include infertility/subfertility, cryptorchidism, and hypospadias. Findings from both human and animal studies are represented.
摘要
本章涵盖了内分泌干扰化学物质（EDC）对生殖系统紊乱的已知影响。所涉及的内分泌干扰化学物质都经过了深入研究，包括增塑剂（双酚类和邻苯二甲酸盐）、个人护理产品中的化学物质（对羟基苯甲酸酯）、持久性环境污染物（多氯联苯）以及农药或除草剂中的化学物质。本章对女性和男性生殖系统紊乱都进行了综述。女性紊乱包括不孕不育/生育力低下、月经周期不规律、过早绝经、卵巢早衰、多囊卵巢综合征、子宫内膜异位症和子宫肌瘤。男性紊乱包括不孕不育/生育力低下、隐睾症和尿道下裂。同时呈现了人类和动物研究的结果。
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