五种肥胖指标与表观遗传年龄加速的关联：来自 2474 名台湾生物样本库参与者的证据。

Associations of five obesity metrics with epigenetic age acceleration: Evidence from 2,474 Taiwan Biobank participants.

机构信息

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Master of Public Health Degree Program, College of Public Health, National Taiwan University, Taipei, Taiwan.

出版信息

Obesity (Silver Spring). 2021 Oct;29(10):1731-1738. doi: 10.1002/oby.23255. Epub 2021 Sep 2.

DOI:10.1002/oby.23255

PMID:34472716

Abstract

OBJECTIVE

Obesity is associated with epigenetic age acceleration (EAA), resulting in an increased risk of many age-related disorders. However, most studies have focused on the relationship of EAA with BMI. Whether any other obesity metric is more relevant to EAA remains unknown.

METHODS

Here, the methylation ages of 2,474 Taiwan Biobank (TWB) participants were calculated according to Levine's phenotypic age (PhenoAge) and Lu's GrimAge. Residuals from regressing methylation age on chronological age were used to quantify PhenoEAA and GrimEAA. Five obesity metrics were evaluated, namely BMI, body fat percentage, waist circumference, hip circumference, and waist-hip ratio. Sex-stratified EAA was regressed on each of the five obesity metrics.

RESULTS

For male individuals, an increase of one SD in waist-hip ratio (0.06) was associated with a 0.602-year PhenoEAA (p = 6.3E-6) and a 0.481-year GrimEAA (p = 1.2E-8). For female individuals, every SD increase in BMI (3.7 kg/m ) was associated with a 0.600-year PhenoEAA (p = 3.3E-5) and a 0.305-year GrimEAA (p = 3.1E-5).

CONCLUSIONS

"Abdominal obesity" and "general obesity" are significantly associated with male and female EAA, respectively. The prevention of abdominal obesity and general obesity is associated with a lower risk of EAA in men and women, respectively.

摘要

目的

肥胖与表观遗传年龄加速（EAA）相关，导致许多与年龄相关的疾病风险增加。然而，大多数研究都集中在 EAA 与 BMI 的关系上。其他任何肥胖指标与 EAA 的相关性如何仍不清楚。

方法

在这里，根据 Levine 的表型年龄（PhenoAge）和 Lu 的 GrimAge，计算了 2474 名台湾生物银行（TWB）参与者的甲基化年龄。将甲基化年龄回归到年龄的残差用于量化 PhenoEAA 和 GrimEAA。评估了五种肥胖指标，即 BMI、体脂肪百分比、腰围、臀围和腰臀比。对性别分层的 EAA 与这五种肥胖指标中的每一种进行回归。

结果

对于男性个体，腰臀比（0.06）增加一个标准差与 PhenoEAA 增加 0.602 岁（p = 6.3E-6）和 GrimEAA 增加 0.481 岁（p = 1.2E-8）相关。对于女性个体，BMI（3.7kg/m）每增加一个标准差与 PhenoEAA 增加 0.600 岁（p = 3.3E-5）和 GrimEAA 增加 0.305 岁（p = 3.1E-5）相关。