Significance of NPM1 Gene Mutations in AML.

The aim of this literature review is to examine the significance of the nucleophosmin 1 () gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in , and the mechanism by which this influences the development and progression of AML. The importance of mutation on prognosis and the treatment options available to patients will also be reviewed along with current guidelines recommending the rapid return of mutational screening results and the importance of employing a suitable laboratory assay to achieve this. Finally, future developments in the field including research into new therapies targeting mutated AML are considered.