病毒对 DNA 损伤反应和固有免疫的调节：同一枚硬币的两面。
Viral Modulation of the DNA Damage Response and Innate Immunity: Two Sides of the Same Coin.
机构信息
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, CA, USA.
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
出版信息
J Mol Biol. 2022 Mar 30;434(6):167327. doi: 10.1016/j.jmb.2021.167327. Epub 2021 Oct 22.
The DDR consists of multiple pathways that sense, signal, and respond to anomalous DNA. To promote efficient replication, viruses have evolved to engage and even modulate the DDR. In this review, we will discuss a select set of diverse viruses and the range of mechanisms they evolved to interact with the DDR and some of the subsequent cellular consequences. There is a dichotomy in that the DDR can be both beneficial for viruses yet antiviral. We will also review the connection between the DDR and innate immunity. Previously believed to be disparate cellular functions, more recent research is emerging that links these processes. Furthermore, we will discuss some discrepancies in the literature that we propose can be remedied by utilizing more consistent DDR-focused assays. By doing so, we hope to obtain a much clearer understanding of how broadly these mechanisms and phenotypes are conserved among all viruses. This is crucial for human health since understanding how viruses manipulate the DDR presents an important and tractable target for antiviral therapies.
DDR 由多个途径组成，这些途径可感知、信号传递和响应异常的 DNA。为了促进有效的复制，病毒已经进化到参与甚至调节 DDR。在这篇综述中，我们将讨论一组精选的不同病毒，以及它们进化出的一系列与 DDR 相互作用的机制，以及一些后续的细胞后果。这种情况存在二分法，即 DDR 既对病毒有益，又具有抗病毒作用。我们还将回顾 DDR 与先天免疫之间的联系。以前认为是不同的细胞功能，最近的研究表明，这些过程是相互关联的。此外，我们还将讨论文献中的一些差异，我们认为通过利用更专注于 DDR 的一致性测定，可以解决这些差异。通过这样做，我们希望能够更清楚地了解这些机制和表型在所有病毒中是如何广泛保守的。这对人类健康至关重要，因为了解病毒如何操纵 DDR 为抗病毒治疗提供了一个重要且可行的目标。
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