检测严重急性呼吸综合征冠状病毒 2 抗体的替代方法。
Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies.
机构信息
Micelio Labs, 58, 15th Cross Road, 2nd Phase, J P Nagar, Bengaluru 560078, India.
Ragon Institute of MGH, MIT and Harvard, 400 Technology Square, Cambridge, MA 02139, USA; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02215, USA.
出版信息
Clin Lab Med. 2022 Mar;42(1):57-73. doi: 10.1016/j.cll.2021.10.007. Epub 2021 Nov 3.
The COVID-19 pandemic has resulted in the development, validation, and rapid adoption of multiple novel diagnostic approaches. Hundreds of SARS-CoV-2 serologic assays have been developed and deployed to contain the spread of the virus, and to supply timely and important health information. Most of these serologic assays were based on a conventional enzyme-linked immunosorbent assay or the lateral flow assay format. The immunoassays that were developed were based on alternative technologies and are highlighted in this article with a brief discussion of the assay principle and the pros and cons for each assay. Measurement of neutralizing antibodies is also discussed.
COVID-19 大流行导致了多种新型诊断方法的开发、验证和快速采用。为了控制病毒的传播，并提供及时和重要的健康信息，已经开发和部署了数百种 SARS-CoV-2 血清学检测方法。这些血清学检测方法大多基于传统的酶联免疫吸附测定或侧向流动检测方法。本文还重点介绍了开发的免疫检测方法，简要讨论了每种检测方法的检测原理和优缺点。还讨论了中和抗体的测量。
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