自噬系统作为神经退行性疾病的潜在治疗靶点。
Autophagy system as a potential therapeutic target for neurodegenerative diseases.
机构信息
Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
出版信息
Neurochem Int. 2022 May;155:105308. doi: 10.1016/j.neuint.2022.105308. Epub 2022 Feb 15.
Autophagy is an evolutionally conserved process by which cytoplasmic contents including protein aggregates and damaged organelles such as mitochondria and lysosomes, are sequestered by double-membrane structure, autophagosomes, and delivered to the lysosomes for degradation. Recently, considerable efforts have been made to reveal the role of autophagy in neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease. Impairment of autophagy aggravates the accumulation of misfolded protein and damaged organelles in neurons, while sufficient autophagic activity reduces such accumulation in nervous system and ameliorates the pathology. Here we summarize recent progress regarding the role of autophagy in several neurodegenerative diseases and the potential autophagy-associated therapies for them.
自噬是一种进化上保守的过程，通过该过程，细胞质内容物（包括蛋白质聚集体和受损的细胞器，如线粒体和溶酶体）被双层膜结构自噬体隔离，并递送至溶酶体进行降解。最近，人们做出了相当大的努力来揭示自噬在神经退行性疾病（如阿尔茨海默病、帕金森病和亨廷顿病）中的作用。自噬的损伤会加剧神经元中错误折叠的蛋白质和受损细胞器的积累，而足够的自噬活性会减少神经系统中的这种积累，并改善病理学。在这里，我们总结了自噬在几种神经退行性疾病中的作用以及针对这些疾病的潜在自噬相关治疗方法的最新进展。
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