肝细胞癌的分段治疗 - 分割大小的影响。
Hypofractionation in Hepatocellular Carcinoma - The Effect of Fractionation Size.
机构信息
Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
出版信息
Clin Oncol (R Coll Radiol). 2022 May;34(5):e195-e209. doi: 10.1016/j.clon.2022.02.021. Epub 2022 Mar 18.
The use of stereotactic body radiotherapy (SBRT) in hepatocellular carcinoma (HCC) has increased over the years. Several prospective studies have demonstrated its safety and efficacy, and randomised trials are underway. The advancement in technology has enabled the transition from three-dimensional conformal radiotherapy to highly focused SBRT. Liver damage is the primary limiting toxicity with radiation, with the incidence of grade 3 varying from 0 to 30%. The reported radiotherapy fractionation schedule for HCC, and in practice use, ranges from one to 10 fractions, based on clinician preference and technology available, tumour location and tumour size. This review summarises the safety and efficacy of various SBRT fractionation schedules for HCC.
立体定向体部放疗（SBRT）在肝细胞癌（HCC）中的应用近年来有所增加。多项前瞻性研究已经证明了其安全性和有效性，并且正在进行随机试验。技术的进步使得从三维适形放疗转变为高度聚焦的 SBRT 成为可能。肝脏损伤是放射治疗的主要限制毒性，3 级发生率为 0 至 30%。根据临床医生的偏好和可用技术、肿瘤位置和肿瘤大小，报告的 HCC 放疗分割方案和实际应用范围为 1 至 10 个分割。本文综述了各种 HCC SBRT 分割方案的安全性和有效性。
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