与单独接种疫苗相比，感染 SARS-CoV-2 后接种疫苗可提高针对奥密克戎变异株的抗体亲合力。
Vaccination After SARS-CoV-2 Infection Increased Antibody Avidity Against the Omicron Variant Compared to Vaccination Alone.
机构信息
Genomic Medicine Center, Children's Mercy Research Institute, Kansas City, Missouri, USA.
Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri, USA.
出版信息
J Infect Dis. 2022 Nov 11;226(10):1712-1716. doi: 10.1093/infdis/jiac247.
The SARS-CoV-2 Omicron variant has caused infections among individuals vaccinated or with prior COVID-19, suggesting immune escape. Here, we showed a decrease in binding and surrogate neutralizing antibody responses to the Omicron variant after 2 doses of the Pfizer COVID-19 mRNA vaccine. Individuals recovered from infection before vaccination had higher antibody levels and avidity to the Omicron variant compared to individuals vaccinated without infection. This suggested that COVID-19 infection before vaccination elicited a higher magnitude and affinity antibody response to the Omicron variant, and repeated exposure through infection or vaccine may be required to improve immunity to emerging SARS-CoV-2 variants.
SARS-CoV-2 奥密克戎变异株可导致已接种疫苗或曾感染过 COVID-19 的个体感染，表明存在免疫逃逸。在此，我们发现，在接种 2 剂辉瑞 COVID-19 mRNA 疫苗后，针对奥密克戎变异株的结合和假病毒中和抗体反应下降。与未感染而接种疫苗的个体相比，在接种疫苗之前已从感染中恢复的个体对奥密克戎变异株的抗体水平和亲和力更高。这表明，接种疫苗前的 COVID-19 感染可引发针对奥密克戎变异株的更高幅度和亲和力的抗体反应，并且可能需要通过感染或疫苗接种的重复暴露来提高对新兴 SARS-CoV-2 变异株的免疫力。
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