Aqueous Extract from Can Improve the Function Degradation and Delay Aging on Through Antioxidant Mechanism.

Astragali Radix is the dry root of the leguminous plants (Fisch.) Bge. Var. (Bge.) Hsiao and (Fisch.) Bge. Astragali Radix is mostly used clinically as a decoction. A number of pharmacological studies show that extract can increase telomerase activity and has antioxidation, anti-inflammatory, immune regulation, anticancer, lowering blood lipid, lowering blood sugar, and other effects. However, the anti-aging mechanism of aqueous extract from Astragali Radix (ARE) is still unclear. In this study, we evaluated the anti-aging effect of ARE on and investigated the underlying mechanism. The results of life span assay showed that 1.25 mg/mL of ARE can significantly prolong the life span of in a natural aging model and protect against HO and paraquat. Meanwhile, ARE can improve the climbing ability and food intake of flies. Metabolomics and the glutamate content assay suggested that ARE prevented an age-dependent increase in glutamate levels in . Furthermore, ARE showed a dose-dependent effect on the scavenging ability of α, α-diphenyl-β-picrylhydrazyl . Superoxide dismutase and catalase activities in the aging group also increased after the intervention of ARE. The data and the findings described here support the notion that ARE may play a preventive role in aging by improving the climbing ability, eliminating harmful free radicals accumulated in and triggering antioxidant responses.