酸奶和其他乳制品的消费与伊朗结直肠癌风险：IROPICAN 研究。
Consumption of Yoghurt and Other Dairy Products and Risk of Colorectal Cancer in Iran: The IROPICAN Study.
机构信息
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 1416634793, Iran.
出版信息
Nutrients. 2022 Jun 16;14(12):2506. doi: 10.3390/nu14122506.
BACKGROUND
There is evidence of an inverse association between yoghurt intake and risk of colorectal cancer (CRC). We aimed at investigating the association between the intake of yoghurt and other dairy foods consumed in Iran and CRC risk.
METHODS
Our analysis included 4070 subjects within the IROPICAN (Iran Study of Opium and Cancer) study. Detailed information was collected by the use of validated questionnaires. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between the intake of total dairy products, and, separately, of yoghurt, milk, cheese, kashk, dough, cream, ice cream, and other milk products, and CRC using unconditional logistic regression analyses. The intake was categorized in tertiles.
RESULTS
Overall, we analyzed 865 cases and 3205 controls. Total dairy products intake was not associated with CRC. The OR for one tertile increase (OR_T) in yoghurt intake was 0.97 (95% CI 0.87-1.08) for CRC and 0.66 (95% CI 0.52-0.84) for proximal colon cancer. Cream intake was associated with CRC (OR_T3 = 1.33, 95% CI 1.08-1.64), colon (OR_T3 = 1.37, 95% CI 1.03-1.81), and proximal cancer (OR_T3 = 1.29, 95% CI 1.04-1.61). The OR of distal colon cancer for ice cream intake was 0.59 (95% CI 0.43-0.82). Other dairy products were not associated with CRC risk.
背景
有证据表明酸奶摄入与结直肠癌（CRC）风险呈负相关。我们旨在研究伊朗酸奶和其他乳制品的摄入与 CRC 风险之间的关系。
方法
我们的分析包括 IROPICAN（伊朗鸦片与癌症研究）研究中的 4070 名受试者。详细信息通过使用经过验证的问卷收集。我们使用非条件逻辑回归分析估计了总乳制品摄入量以及酸奶、牛奶、奶酪、kashk、面团、奶油、冰淇淋和其他乳制品摄入量与 CRC 之间的调整比值比（OR）和 95%置信区间（CI）。摄入量分为三分位。
结果
总体而言，我们分析了 865 例病例和 3205 例对照。总乳制品摄入量与 CRC 无关。酸奶摄入量增加一个三分位（OR_T）的 OR 为 0.97（95%CI 0.87-1.08），CRC 和近端结肠癌的 OR 分别为 0.66（95%CI 0.52-0.84）。奶油摄入量与 CRC（OR_T3=1.33，95%CI 1.08-1.64）、结肠（OR_T3=1.37，95%CI 1.03-1.81）和近端癌（OR_T3=1.29，95%CI 1.04-1.61）相关。冰淇淋摄入量与远端结肠癌的 OR 为 0.59（95%CI 0.43-0.82）。其他乳制品与 CRC 风险无关。
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