生活方式干预对端粒长度的影响：系统评价和荟萃分析。

Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis.

机构信息

Université Clermont Auvergne, General medicine, F-63000 Clermont-Ferrand, France.

University of Isfahan, Exercise physiology department, Isfahan, Iran.

出版信息

Mech Ageing Dev. 2022 Sep;206:111694. doi: 10.1016/j.mad.2022.111694. Epub 2022 Jun 26.

DOI:10.1016/j.mad.2022.111694

PMID:35760212

Abstract

BACKGROUND

We conducted a systematic review and meta-analysis to assess the effects of lifestyle intervention on telomere length (TL).

METHOD

Four databases were searched for studies reporting TL in leukocytes, before and after a lifestyle intervention. We computed random-effects meta-analysis on TL within intervention and control group after versus before intervention, and on changes in TL between groups. Sensitivity analyses and Meta-regression were conducted.

RESULTS

We included 20 studies in the systematic review (2995 participants, mean 50.3 years old, 77% women, 2045 following an intervention and 950 controls) and 19 in the meta-analysis. TL were similar at baseline between intervention and control groups. The physical activity ± diet group had an increase in TL (Effect size 0.17, 95%CI 0.03-0.31, p = 0.020) using changes within the intervention group, whereas TL shortened in the control group (-0.32, -0.61 to -0.02, p = 0.037). TL was longer in the physical activity ± diet intervention group (0.24, 0.08-0.40, p = 0.004) compared to controls after the intervention. Sensitivity analysis gave similar results. Meta-regressions demonstrated that combining strength and endurance exercise increased TL more than endurance alone or strength alone.

CONCLUSION

A lifestyle intervention with physical activity ± diet can increase telomere length, independently of population characteristics or baseline TL.

摘要

背景

我们进行了一项系统评价和荟萃分析，以评估生活方式干预对端粒长度（TL）的影响。

方法

我们在四个数据库中搜索了报告白细胞 TL 的研究，这些研究在生活方式干预前后进行了报道。我们对干预组和对照组的 TL 进行了随机效应荟萃分析，比较了干预前后的 TL 变化，并进行了敏感性分析和 Meta 回归。

结果

我们纳入了系统评价中的 20 项研究（2995 名参与者，平均年龄 50.3 岁，77%为女性，2045 名参与者接受了干预，950 名参与者为对照组）和荟萃分析中的 19 项研究。干预组和对照组在基线时 TL 相似。在体力活动±饮食组中，使用干预组内的变化，TL 增加（效应大小 0.17，95%CI 0.03-0.31，p=0.020），而对照组 TL 缩短（-0.32，-0.61 至-0.02，p=0.037）。在干预后，体力活动±饮食干预组的 TL 比对照组长（0.24，0.08-0.40，p=0.004）。敏感性分析得出了类似的结果。Meta 回归表明，结合力量和耐力运动比单独进行耐力或力量运动更能增加 TL。