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慢性肾脏病中的糖尿病管理:美国糖尿病协会(ADA)和改善全球肾脏病预后组织(KDIGO)的共识报告。

Diabetes Management in Chronic Kidney Disease: A Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO).

机构信息

Kidney Research Institute, University of Washington, Seattle, WA.

Diabetes Research Centre, University of Leicester, Leicester, U.K.

出版信息

Diabetes Care. 2022 Dec 1;45(12):3075-3090. doi: 10.2337/dci22-0027.

Abstract

People with diabetes and chronic kidney disease (CKD) are at high risk for kidney failure, atherosclerotic cardiovascular disease, heart failure, and premature mortality. Recent clinical trials support new approaches to treat diabetes and CKD. The 2022 American Diabetes Association (ADA) Standards of Medical Care in Diabetes and the Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease each provide evidence-based recommendations for management. A joint group of ADA and KDIGO representatives reviewed and developed a series of consensus statements to guide clinical care from the ADA and KDIGO guidelines. The published guidelines are aligned in the areas of CKD screening and diagnosis, glycemia monitoring, lifestyle therapies, treatment goals, and pharmacologic management. Recommendations include comprehensive care in which pharmacotherapy that is proven to improve kidney and cardiovascular outcomes is layered on a foundation of healthy lifestyle. Consensus statements provide specific guidance on use of renin-angiotensin system inhibitors, metformin, sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 receptor agonists, and a nonsteroidal mineralocorticoid receptor antagonist. These areas of consensus provide clear direction for implementation of care to improve clinical outcomes of people with diabetes and CKD.

摘要

患有糖尿病和慢性肾脏病 (CKD) 的人患肾衰竭、动脉粥样硬化性心血管疾病、心力衰竭和过早死亡的风险很高。最近的临床试验支持治疗糖尿病和 CKD 的新方法。2022 年美国糖尿病协会 (ADA) 的《糖尿病医疗护理标准》和肾脏病:改善全球结果 (KDIGO) 2022 年慢性肾脏病糖尿病管理临床实践指南都为管理提供了循证建议。ADA 和 KDIGO 的一个联合代表小组审查并制定了一系列共识声明,以指导 ADA 和 KDIGO 指南的临床护理。已发布的指南在 CKD 筛查和诊断、血糖监测、生活方式疗法、治疗目标和药物治疗管理方面保持一致。建议包括综合护理,即在健康生活方式的基础上,采用已证明可改善肾脏和心血管结局的药物治疗。共识声明就肾素-血管紧张素系统抑制剂、二甲双胍、钠-葡萄糖共转运蛋白 2 抑制剂、胰高血糖素样肽 1 受体激动剂和非甾体类盐皮质激素受体拮抗剂的使用提供了具体指导。这些共识领域为改善糖尿病和 CKD 患者的临床结局提供了明确的实施护理方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec8/9870667/f37014d6e5d3/dci220027f1.jpg

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