人类对 13 种疫苗的免疫反应转录图谱揭示了一种预测疫苗诱导抗体反应的共同指标。
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses.
机构信息
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
出版信息
Nat Immunol. 2022 Dec;23(12):1788-1798. doi: 10.1038/s41590-022-01328-6. Epub 2022 Oct 31.
Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples, from 820 adults across 28 studies of 13 vaccines and analyzed vaccination-induced signatures of antibody responses. Most vaccines induced signatures of innate immunity and plasmablasts at days 1 and 7, respectively, after vaccination. However, the yellow fever vaccine induced an early transient signature of T and B cell activation at day 1, followed by delayed antiviral/interferon and plasmablast signatures that peaked at days 7 and 14-21, respectively. Thus, there was no evidence for a 'universal signature' that predicted antibody response to all vaccines. However, accounting for the asynchronous nature of responses, we defined a time-adjusted signature that predicted antibody responses across vaccines. These results provide a transcriptional atlas of immunity to vaccination and define a common, time-adjusted signature of antibody responses.
系统疫苗学已经定义了疫苗接种免疫的分子特征和机制。然而，对于不同疫苗的免疫比较分析还很缺乏。我们整合了超过 3000 个样本的转录数据，来自 28 项研究中的 820 名成年人，分析了疫苗接种诱导的抗体反应特征。大多数疫苗在接种后第 1 天和第 7 天分别诱导先天免疫和浆母细胞的特征。然而，黄热病疫苗在第 1 天诱导了一个早期短暂的 T 和 B 细胞激活特征，随后是延迟的抗病毒/干扰素和浆母细胞特征，分别在第 7 天和第 14-21 天达到峰值。因此，没有证据表明存在一种“通用特征”可以预测所有疫苗的抗体反应。然而，考虑到反应的异步性质，我们定义了一个时间调整的特征，可以预测疫苗接种的抗体反应。这些结果提供了疫苗接种免疫的转录图谱，并定义了一种常见的、时间调整的抗体反应特征。
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