VaxGO：一个用于系统疫苗学数据分析的交互式网络工具。
VaxGO: an interactive web tool for systems vaccinology data analysis.
作者信息
Prates-Syed Wasim Aluísio, Lima Aline Aparecida, Cortes Nelson, Carvalho Evelyn, Queiroz Silva Jaqueline Dinis, Hamaguchi Bárbara, Durães-Carvalho Ricardo, Cabral-Marques Otávio, Hagan Thomas, Krieger José E, Cabral-Miranda Gustavo
机构信息
Institute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.
Biomedical Sciences Institute, University of São Paulo, São Paulo, 05508-000, Brazil.
出版信息
Bioinform Adv. 2025 May 2;5(1):vbaf101. doi: 10.1093/bioadv/vbaf101. eCollection 2025.
MOTIVATION
RNA sequencing is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNA sequencing data often requires programming skills, which can limit accessibility for researchers lacking such expertise.
RESULTS
We present VaxGO, an intuitive web-based tool designed to facilitate the analysis of differentially expressed genes in the context of immune processes and cells during vaccination. This tool integrates data from Gene Ontology, CellMarker 2.0, the MSigDB Vax collection, and other key studies, including transcriptional atlases of vaccines against COVID-19 and other diseases. VaxGO is an interactive, web-based tool, offering a user-friendly platform for exploring immune responses and vaccine efficacy without programming expertise.
AVAILABILITY AND IMPLEMENTATION
The VaxGO tool is available at https://github.com/wapsyed/VaxGO.
动机
RNA测序对于研究免疫学和疫苗研究中的转录模式至关重要。然而，RNA测序数据的分析通常需要编程技能，这可能会限制缺乏此类专业知识的研究人员的可及性。
结果
我们展示了VaxGO，这是一个基于网络的直观工具，旨在促进在疫苗接种过程中对免疫过程和细胞背景下差异表达基因的分析。该工具整合了来自基因本体论、CellMarker 2.0、MSigDB疫苗集以及其他关键研究的数据，包括针对COVID-19和其他疾病的疫苗转录图谱。VaxGO是一个基于网络的交互式工具，为探索免疫反应和疫苗效力提供了一个无需编程专业知识的用户友好平台。
可用性和实施
VaxGO工具可在https://github.com/wapsyed/VaxGO上获取。
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