小胶质细胞状态和命名：一个处于十字路口的领域。
Microglia states and nomenclature: A field at its crossroads.
机构信息
Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Achucarro Basque Center for Neuroscience, Glial Cell Biology Lab, Leioa, Spain; Department of Neuroscience, University of the Basque Country EHU/UPV, Leioa, Spain; Ikerbasque Foundation, Bilbao, Spain.
出版信息
Neuron. 2022 Nov 2;110(21):3458-3483. doi: 10.1016/j.neuron.2022.10.020.
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
近年来，小胶质细胞研究取得了显著进展，但受到一系列二分法的限制，例如“静息状态与激活状态”和“M1 型与 M2 型”。这种将小胶质细胞分为好或坏的二元分类法与近年来阐明的小胶质细胞在发育、可塑性、衰老和疾病中的广泛状态和功能不一致。为了描述不同的小胶质细胞状态，不断出现新的命名，特别是使用转录组学和蛋白质组学来定义，这可能很容易导致分类和功能的误导性关联，尽管这并非本意。为了解决这些问题，我们召集了一组多学科专家，讨论我们目前对小胶质细胞状态作为一个动态概念的理解，以及解决小胶质细胞功能的重要性。在这里，我们为研究人员、评论家和编辑提供了一个关于使用小胶质细胞命名法的概念框架和建议，这将成为未来白皮书的基础。
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