Dwivedi Alok Kumar, Vishwakarma Deepanjali, Dubey Pallavi, Reddy Sireesha Y
Division of Biostatistics & Epidemiology, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, 5001, El Paso Drive, El Paso, TX, 79905, USA.
Biostatistics and Epidemiology Consulting Lab, Office of Research, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
Curr Cardiol Rep. 2022 Dec;24(12):1811-1835. doi: 10.1007/s11886-022-01819-w. Epub 2022 Nov 25.
Although environmental exposure such as air pollution is detrimental to cardiovascular disease (CVD), the effects of different air pollutants on different CVD endpoints produced variable findings. We provide updated evidence between air pollutants and CVD outcomes including mitigation strategies with meta-analytic evidence.
An increased exposure to any class of air pollutants including particulate matter (PM), gas, toxic metals, and disruptive chemicals has been associated with CVD events. Exposure to PM < 2.5 μm has been consistently associated with most heart diseases and stroke as well as CVDs among at-risk individuals. Despite this, there is no clinical approach available for systemic evaluation of air pollution exposure and management. A large number of epidemiological evidence clearly suggests the importance of air pollution prevention and control for reducing the risk of CVDs and mortality. Cost-effective and feasible strategies for air pollution monitoring, screening, and necessary interventions are urgently required among at-risk populations and those living or working, or frequently commuting in polluted areas.
尽管空气污染等环境暴露对心血管疾病(CVD)有害,但不同空气污染物对不同CVD终点的影响产生了不同的结果。我们提供了空气污染物与CVD结局之间的最新证据,包括具有荟萃分析证据的缓解策略。
接触任何一类空气污染物,包括颗粒物(PM)、气体、有毒金属和破坏性化学物质,都与CVD事件有关。接触小于2.5微米的PM一直与大多数心脏病、中风以及高危个体的CVD有关。尽管如此,目前还没有可用于空气污染暴露和管理系统评估的临床方法。大量的流行病学证据清楚地表明,预防和控制空气污染对于降低CVD风险和死亡率的重要性。在高危人群以及生活、工作或经常在污染地区通勤的人群中,迫切需要具有成本效益且可行的空气污染监测、筛查和必要干预策略。