严重急性呼吸综合征冠状病毒2变体中与总病毒RNA相关的亚基因组RNA丰度
Subgenomic RNA Abundance Relative to Total Viral RNA Among Severe Acute Respiratory Syndrome Coronavirus 2 Variants.
作者信息
Su Maxwell, Ping Sara, Nguyen Phuong-Vi, Rojas Alejandra, Hussaini Laila, Carmola Ludy Registre, Taz Azmain, Sullivan Julie, Martin Greg S, Piantadosi Anne, Martinez Magaly, Lam Wilbur A, Anderson Evan J, Waggoner Jesse J
机构信息
Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA.
Departamento de Producción, Universidad Nacional de Asunción, Instituto de Investigaciones en Ciencias de la Salud, Asunción, Paraguay.
出版信息
Open Forum Infect Dis. 2022 Nov 10;9(11):ofac619. doi: 10.1093/ofid/ofac619. eCollection 2022 Nov.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subgenomic RNA (sgRNA) may indicate actively replicating virus, but sgRNA abundance has not been systematically compared between SARS-CoV-2 variants. sgRNA was quantified in 169 clinical samples by real-time reverse-transcription polymerase chain reaction, demonstrating similar relative abundance among known variants. Thus, sgRNA detection can identify individuals with active viral replication regardless of variant.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）亚基因组RNA（sgRNA）可能表明病毒正在积极复制，但尚未对SARS-CoV-2变体之间的sgRNA丰度进行系统比较。通过实时逆转录聚合酶链反应对169份临床样本中的sgRNA进行定量分析，结果表明已知变体之间的相对丰度相似。因此，sgRNA检测可以识别出病毒正在活跃复制的个体，而不论其变体如何。
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