用于慢性病毒感染和癌症的DNA和mRNA疫苗：原理、机制与进展
DNA and mRNA Vaccines for Chronic Viral Infections and Cancer: Rationale, Mechanisms, and Progress.
作者信息
Liu Margaret A
机构信息
ProTherImmune, 3656 Happy Valley Road, Lafayette, CA 94549, USA.
Department of Medicine at Solna, Karolinska Institutet, 17177 Stockholm, Sweden.
出版信息
Cancers (Basel). 2022 Nov 29;14(23):5874. doi: 10.3390/cancers14235874.
Interest in the capabilities of nucleic acid vaccines, (DNA and mRNA vaccines) for both prophylactic and therapeutic uses have greatly increased following the successful deployment of two mRNA and, on a more limited scale, one DNA vaccine for COVID-19. In addition to targeting other pathogens for prophylactic vaccines, efforts are also being made towards using them for therapies for chronic infections and cancer. An examination of past and current successes for such therapies using other technologies with an emphasis on the immunological mechanisms will be provided followed by an assessment of the relevant characteristics of DNA and mRNA vaccines to predict their utility for therapies for chronic viral infections and cancer. Efforts and progress for these targets will be described.
在成功部署两种mRNA疫苗以及在更有限范围内部署一种DNA新冠疫苗之后，人们对核酸疫苗（DNA疫苗和mRNA疫苗）用于预防和治疗用途的能力的兴趣大幅增加。除了针对其他病原体研发预防性疫苗外，人们也在努力将其用于慢性感染和癌症的治疗。本文将审视过去和当前使用其他技术进行此类治疗的成功案例，重点关注免疫机制，随后评估DNA疫苗和mRNA疫苗的相关特性，以预测它们在慢性病毒感染和癌症治疗中的效用。还将描述针对这些目标所做的努力和取得的进展。
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