新型钇（III）荧光探针及其生物成像
The Novel Fluorescent Probe Toward Yttrium(III) and its Bioimaging.
作者信息
Qin Yuxin, Meng Qian, Yao Junxiong, Chen Mengyu, Dong Yajie, Chen Dashuo, He Shuping, Bai Cuibing, Zhang Lin, Wei Biao, Miao Hui, Qu Changqing, Qiao Rui
机构信息
Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Anhui Provincial Key Laboratory for Degradation and Monitoring of Pollution of the Environment, School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang, Anhui Province, 236037, People's Republic of China.
Research Center of Anti-Aging Chinese Herbal Medicine of Anhui Province, Fuyang Normal University, Fuyang, Anhui Province, 236037, People's Republic of China.
出版信息
J Fluoresc. 2023 Mar;33(2):731-737. doi: 10.1007/s10895-022-03106-x. Epub 2022 Dec 13.
In this paper, the novel fluorescence probe XP based on Schiff-base was designed, synthesized and characterized, which could detect Yselectively and sensitively. The recognition mechanism of XP toward Y was studied by Job's plot and HRMS. It was investigated that stoichiometric ratio of the probe XP conjugated with Y was 1:2. And the detection limit was calculated as 0.30 μM. In addition, Y was recognized by the test paper made from XP. And the probe XP could detect Y selectively in Caenorhabditis elegans and the main organs of mice. Thus, XP was considered to have some potential for application in bioimaging.
本文设计、合成并表征了基于席夫碱的新型荧光探针XP，其能够选择性、灵敏地检测Y。通过Job曲线和高分辨质谱研究了XP对Y的识别机理。研究发现探针XP与Y的化学计量比为1:2，计算得出检测限为0.30 μM。此外，由XP制成的试纸能够识别Y。并且探针XP能够在秀丽隐杆线虫和小鼠的主要器官中选择性地检测Y。因此，XP被认为在生物成像方面具有一定的应用潜力。
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